The Potential Utilization of Young Teak Leaves (Tectona grandis Linn.f.) as Basic Ingredients on Producing Anti-cancer Herbal Tea

Authors

  • Nur Ahmad Rudin Universitas Gadjah Mada
  • Asma' Hulaimah Universitas Gadjah Mada
  • Rini Rahmawati Universitas Gadjah Mada

Keywords:

Tectona grandis, anticancer, flavonoids, herbal tea, young teak leaves

Abstract

Gunungkidul Regency is the main teak tree (Tectona grandis Linn.f.) producing area in Special Region of Yogyakarta, Indonesia. Their trunks are commonly used for furniture and buildings, while leaves are still less of use. Teak leaves contain antioxidant compounds in form of flavonoids that play important role in protecting the body against damaging free radicals in cancer sufferers. The number of cancer sufferers in Indonesia is still high, but cancer problem not yet be handled optimally because cannot be fully reached by the community. The aims of this review are studying the production process of herbal tea from young teak leaf and mechanism of flavonoids as an anticancer. This review was conducted by literature study. The writing source is then analyzed and synthesized to draw conclusions. The results obtained production process of young teak leaf herbal tea through several stages, picking, washing, withering, cutting, fermentation, drying, and packaging. The anticancer activity in young teak leaf herbal tea is influenced by the content of flavonoids as antioxidants that can neutralize free radicals and prevent cancer. The conclusion of this review are young teak leaves (T. grandis) can be used as basic ingredient in herbal teas that are good for health, and flavonoids in young teak leaves are antioxidants that potential as anticancer substances.

Author Biographies

Nur Ahmad Rudin, Universitas Gadjah Mada

Department of Tropical Biology, Faculty of Biology, Universitas Gadjah Mada

Asma' Hulaimah, Universitas Gadjah Mada

Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Universitas Gadjah Mada

Rini Rahmawati, Universitas Gadjah Mada

Department of Tropical Biology, Faculty of Biology, Universitas Gadjah Mada

References

Aboaba, S., Akande, A., & Flamini, G. (2013). Chemical constituens, toxicity, and antimicrobial activities of the essential oil from leaves of Tectona grandis. Ibadan: Univesity of Ibadan.

Adom, K. K., & Liu, R. H. (2002). Antioxidant activity of grains. J. Agric. Food Chem., 50, 6182–6187. https://doi.org/10.1021/jf0205099

Ajisaka. (2012). Teh Dahsyat Khasiatnya. Surabaya: Stomata.

Anggorowati, D. A., Priandini, G., & Thufail. (2016). Potensi daun alpukat (Persea americana Miller) sebagai minuman teh herbal yang kaya antioksidan. Industri Inovatif, 6(1), 1–7.

Arpah, M. (1993). Pengawasan Mutu Pangan. Bandung: Tarsito.

Astina, I. (2010). Optimasi pembuatan ekstrak etanolik kayu secang (Caesalpinia sappan L.) secara digesti: Aplikasi desain faktorial. [Thesis]. Yogyakarta: Universitas Sanata Dharma.

Ati, N. H., Rahayu, P., Notosoedarmo, S., & Limantara, L. (2006). The composition and the content of pigments from some dyeing plant for ikat weaving in Timorrese Regency, East Nusa Tenggara. Indo. J. Chem., 6(3), 325–331.

Burda, S., & Oleszek, W. (2001). Antioxidant and antiradical activities of flavonoids. J. Agr. Food Chem., 49, 2774–2779. https://doi.org/10.1021/jf001413m

Cao, G., Sofic, E., & Prior, R. L. (1997). Antioxidant and prooxidant behavior of flavonoids: Structure-activity relationships. Free Radical Biology & Medicine, 22(5), 749–760.

Ciocca, D. R., Gary, M. C., Tandon, A. K., Fuqua, S. A. W., Welch, W. J., & McGuire, W. L. (1993). Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: Prognostic implications. Journal of the National Cancer Institute, 85(7), 570–574.

Delgado, F., Paredes, V., & Lopez. (2003). Natural Colorant for Food and Nutraceutical Uses. Ohio: CRC Press.

Diallo, A., Gbeassor, M., & Vovor, A. (2008). Effect of Tectona grandis on phenylhydrazine-induced anaemia in rats. Fitoterapia, 79, 332–336. https://doi.org/10.1016/j.fitote.2008.02.005

Elia, G., Amici, C., Rossi, A., & Santoro, M. G. (1996). Modulation of prostaglandin A1-induced thermotolerance by quercetin in human. Cancer Research, 56, 210–217.

Fathinatullabibah, Kawiji, & Khasanah, L. U. (2014). Stabilitas antosianin ekstrak daun jati (Tectona grandis) terhadap perlakuan pH dan suhu. Jurnal Aplikasi Teknologi Pangan, 3(2), 60–63.

Fukumoto, L. R., & Mazza, G. (2000). Assessing antioxidant and prooxidant activities of phenolic. J. Agric. Food Chem., 48, 3597−3604. https://doi.org/10.1021/jf000220w

Ghaisas, M., Navghare, V., Takawale, A., Zope, V., Tanwar, M., & Deshpande, A. (2009). Effect of Tectona grandis Linn. on dexamethasone-induced insulin resistance in mice. Journal of Ethnopharmacology, 122, 304–307. https://doi.org/10.1016/j.jep.2009.01.008

Ghareeb, M. A., Shoeb, H. A., Madkour, H. M. F., Refaey, L. A., Mohamed, M. A., & Saad, A. M. (2014). Antioxidant and cytotoxic activities of Tectona grandis Linn. leaves. International Journal of Phytopharmacology, 5(2), 143–157.

Gordon, M. (1990). The mechanism of antioxidants action in vitro. Amsterdam: Elsevier.

Goswami, D. V, Nirmal, S. A., Patil, M. J., Dighe, N. S., Laware, R. B., & Pattan, S. R. (2009). An overview of Tectona grandis: Chemistry and pharmacological profile. Phcog Rev., 3(5), 181–185.

Hambali, E., Nasution, & Herliana, E. (2005). Membuat Aneka Herbal Tea. Jakarta: Penebar Swadaya.

Hamilton, R. (1983). The chemistry of rancidity in foods. London: Applied science Publishers.

Hansen, R. K., Oesterreich, S., Lemieux, P., Sarge, K. D., & Fuqua, S. A. W. (1997). Quercetin inhibits heat shock protein induction but not heat shock factor DNA-binding in human breast carcinoma cells. Biochemical and Biophysical Research Communications, 239, 851–856.

Hartati, R., Gana, S., & Ruslan, K. (2005). Telaah Flavonoid dan Asam Fenolat Daun Jati (Tectona grandis L. f., verbenaceae). Bandung: Institut Teknologi Bandung.

He, X., & Liu, R. H. (2007). Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple’s anticancer activity. J.Agric.FoodChem., 55, 4366–4370. https://doi.org/10.1021/jf063563o

Ibrahim, A. (2008). 273 Ramuan Tradisional Untuk Mengatasi Aneka Penyakit. Tangerang: PT Agromedia Pustaka.

Ikawati, M., Wibowo, A. E., Octa, N. S. U., & Adelina, R. (2015). Pemanfaatan benalu sebagai agen antikanker. Yogyakarta: Universitas Gadjah Mada.

Kahkonen, M. P., Hopia, A. I., & Heinonen, M. (2001). Berry phenolics and their antioxidant activity. J. Agric. Food Chem., 49, 4076−4082. https://doi.org/10.1021/jf010152t

Kementrian Kesehatan RI. (2015). Stop Kanker Situasi Penyakit Kanker. Jakarta: Pusat Data Informasi Kementerian Kesehatan RI.

Kementrian Pertanian RI. (2015). Outlook Teh. Jakarta: Sekretariat Jenderal Kementerian Pertanian Pusat Data dan Sistem Informasi Pertanian.

Klohs, W. D., Fry, D. W., & Kraker, A. J. (1997). Inhibitors of tyrosine kinase. Current Opinion in Oncology, 9(6), 562–568.

Koishi, M., Hosokawa, N., Sato, M., Nakai, A., Hirayoshi, K., Hiraoke, M., … Nagata, K. (1992). Quercetin, an inhibitor of heat shock protein synthesis, inhibits the acquisition of thermotolerance in a human colon carcinoma cell line. Jpn. J. Cancer Res., 83, 1216–1222.

Lacret, R., Varela, R. M., Molinillo, J. M. G., Nogueiras, C., & Macias, F. A. (2012). Phytochemistry letters tectonoelins, new norlignans from a bioactive extract of Tectona grandis. Phytochemistry Letters, 5, 382–386. https://doi.org/10.1016/j.phytol.2012.03.008

Lai, L., Chou, S., & Chao, W. (2001). Studies on the antioxidative activities of hsian-tsao (Mesona procumbens Hemsl) Leaf gum. J. Agric. Food Chem., 49, 963–968. https://doi.org/10.1021/jf001146k

Laleh, G. H., Frydoonfar, H., Heidary, R., Jameei, R., & Zare, S. (2006). The effect of light, temperature, pH and species on stability of anthocyanin pigments in four Berberis species. Pakistan Journal of Nutrition, 5(1), 90–92.

Lamson, D. W., & Brignall, M. S. (2000). Antioxidants and cancer III: Quercetin. Alternative Medicine Review, 5(3), 196–208.

Lee, S., Yoo, S., Lee, M., Kwon, I., & Pyun, Y. (2001). Optimization of nib roasting in cocoa bean processing with lotte-better taste and color process. Food Science and Biotechnology, 3, 286–293.

Lismawenning, D., Yulianto, A., & Sulhadi. (2013). Aplikasi ekstrak daun jati (Tectona grandis) sebagai film kaca non permanen. Unnes Physics Journal, 2(1), 51–57.

Manthey, J. A., & Guthrie, N. (2002). Antiproliferative activities of Citrus flavonoids against six human cancer cell lines. Journal of Agricultural and Food Chemistry, 50, 5837−5843. https://doi.org/10.1021/jf020121d

Marsoem, S. N. (2013). Studi mutu kayu jati di hutan rakyat Gunungkidul: I. Pengukuran laju pertumbuhan. Jurnal Ilmu Kehutanan, 7(2), 108–122.

Narayana, K. R., Reddy, M. S., Chaluvadi, M. R., & Krishna, D. R. (2001). Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential. Indian Journal of Pharmacology, 33, 2–16.

Nasution, Z., & Tjiptadi, W. (1975). Pengolahan Teh. Bogor: Institut Pertanian Bogor.

Nayeem, N., & Karvekar, M. (2010). Comparative Phytochemical and Pharmacological Screening of The Methanolic Extracts of The Frontal and Mature Leaves of Tectona grandis. Bengaluru: Krupanidhi College of Pharmacy.

Neha, K., & Bhargava, S. (2013). Phytochemical and Pharmacological Evaluation of Tectona grandis Linn. Jaipur: University of Rajasthan.

Oesterreich, S., Weng, C., Qiu, M., Hilsenbeck, S. G., Osborne, C. K., & Fuqua, S. A. W. (1993). The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines. Cancer Research, 53, 4443–4448.

Pietta, P. (2000). Flavonoids as antioxidants. J. Nat. Prod., 63, 1035–1042. https://doi.org/10.1021/np9904509

Rahmawati, N. (2015). Aktivitas Antioksidan dan Total Fenol Teh Herbal Daun Pacar Air (Impatiens balsamina) dengan Variasi Lama Fermentasi dan Metode Pengeringan. [Thesis]. Surakarta: Universitas Muhammadiyah Surakarta.

Rohdiana, D. (2015). Teh: proses, karakteristik & komponen fungsionalnya. Foodreview Indonesia, 10(8), 34–37.

Safithri, M., & Fahma, F. (2008). Potency of Piper crocatum decoction as an antihiperglycemia in rat strain Sprague dawley. HAYATI Journal of Biosciences, 15(1), 25–28.

Sandermann, W., & Simatupang, M. (1966). On the chemistry and biochemistry of teak wood (Tectona grandis Linn. F.). Jg. Heft Mai, 190–199.

Seeram, N. P., & Muraleedharan, G. N. (2002). Inhibition of lipid peroxidation and structure−activity-related studies of the dietary constituents anthocyanins, anthocyanidins, and catechins. Journal of Agricultural and Food Chemistry, 50, 5308–5312. https://doi.org/10.1021/jf025671q

Setyamidjaja, D. (2000). Budidaya dan Pengolahan Teh. Yogyakarta: Kanisius.

Singh, J., Bhuyan, T., & Ahmed, A. (1996). Ethnobotanical studies on the mishing tribes of assam with special reference to food and medicinal plants. Eco Tax Bot, 12, 350–356.

Siringoringo, F. (2012). Studi Pembuatan Teh Daun Kopi. Medan: Universitas Sumatera Utara.

Sudarmanto, A. (2015). Program pendampingan teh seduh dan celup dari daun kersen guna menumbuhkan kratifitas wirausaha di Kelurahan Lamper Tengah, Kecamatan Semarang Selatan, Kota Semarang. Dimas, 15(1), 71–84.

Sukhla, N., Kumar, M., Akanksha, Ahmad, G., Rahuja, N., Singh, A., … Maurya, R. (2010). Tectone, A New Antihyperglycemic Anthraquinone from Tectona grandis Leaves. Westerville: Nat Prod Commun.

Toripah, S. S., Abidjulu, J., & Wehantouw, F. (2014). Aktivitas antioksidan dan kandungan total fenolik ekstrak daun kelor (Moringa oleifera Lam.). PHARMACON Jurnal Ilmiah Farmasi – UNSRAT, 3(4), 37–43.

Van der Sluis, A. A., Dekker, M., Skrede, G., & Jongen, W. M. F. (2002). Activity and concentration of polyphenolic antioxidants in apple juice. 1. effect of existing production methods. J. Agric. Food Chem., 50, 7211–7219. https://doi.org/10.1021/jf020115h

Winarsi, H. (2007). Antioksidan Alami dan Radikal Bebas. Yogyakarta: Kanisius.

Yang, X., Wang, Y., Li, K., Li, J., Li, C., Shi, X., … Song, X. (2011). Cocoa tea (Camellia ptilophylla Chang), a natural decaffeinated species of tea – Recommendations on the proper way of preparation for consumption. Journal of Functional Foods, 3(4), 305–312. https://doi.org/10.1016/j.jff.2011.06.001

Yanislieva, N., Pokorny, J., & Gordon. (2001). Antioxidants in food, Practical applications. Cambridge: Woodhead Publishing.

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2022-03-31

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