Efek Pemberian Ekstrak Kulit Kabau (Archidendron jiringoides komariah) Terhadap Konsentrasi Spermatozoa Mencit Jantan yang Diinduksi Timbal (Pb)
DOI:
https://doi.org/10.23887/jjpb.v11i1.79441Keywords:
antioxidant, archidendron, infertility , spermatozoaAbstract
Infertility is currently an important problem in the world, including in Indonesia. Infertility can occur in men and women. In
men, factors causing infertility can come from external sources. One environmental factor that can cause infertility is exposure
to heavy metals from the environment. One way to prevent and treat infertility includes consuming natural antioxidants derived
from plants. One plant that has antioxidant compounds and has antioxidant activity is the kabau plant. This research was
conducted to test the effect of kabau seed pod extract (Archidendron jiringoides Komariah) on male mice exposed to Pb metal
to determine its effect on the concentration of spermatozoa in male mice. The methods used in this research include:
preparation of test animals, making simplicia and kabau seed pod extract, exposing the extract to test animals, isolating
organs, and making spermatozoa suspensions. Giving kabau seed pod extract to mice that had previously been exposed to
lead (Pb) increased the concentration of mice spermatozoa with the most effective dose of kabau bark extract, namely 190
mg/kg BW. However, statistical analysis shows that the increase is not significant.
References
Akbar, A. (2020). Gambaran Faktor Penyebab Infertilitas Pria Di Indonesia : Meta Analisis. Jurnal Pandu Husada, 1(2), 66. https://doi.org/10.30596/jph.v1i2.4433
Calogero, A. E., Fiore, M., Giacone, F., Altomare, M., Asero, P., Ledda, C., Romeo, G., Mongioì, L. M., Copat, C., Giuffrida, M., Vicari, E., Sciacca, S., & Ferrante, M. (2021). Exposure to multiple metals/metalloids and human semen quality: A crosssectional study. Ecotoxicology and Environmental Safety, 215, 112165.
Dorostghoal, M., Seyyednejad, S. M., & Tabrizi Nejad, M. N. (2020). Cichorium intybus L. extract ameliorates testicular oxidative stress induced by lead acetate in male rats. Clinical and Experimental Reproductive Medicine, 47(3), 161–167. https://doi.org/10.5653/cerm.2019.03496
Falahati-Pour, S. K., Khoradmehr, A., Baghery, F., Amin, F., Parvaz, N., & Pourmasumi, S. (2024). Antioxidant Properties of Pistacia vera against the Effects of Phenylhydrazine-Induced Hemolytic Anemia on Male Fertility in Mice. Andrologia, 2024. https://doi.org/10.1155/2024/5512743
Fauziyah, A., & Dwijananti, P. (20131). Pengaruh Radiasi Sinar X Terhadap Motolitas Sperma pada Tikus Mencit. Jurnal Pendidikan Fisika Indonesia , 9, 93–98. PENGARUH RADIASI SINAR X TERHADAP MOTILITAS SPERMA PADA TIKUS MENCIT (Mus muculus)
Fitria Ningrum, R., Sipriyadi, S., & Nursa’adah, E. (2021). Potensi Pemanfaatan Kulit Buah Kabau (Archidendron bubalinum) sebagai Antifungi Candida albicans ATCC 10231. Biotropika: Journal of Tropical Biology, 9(2), 115–120. https://doi.org/10.21776/ub.biotropika.2021.009.02.03
Heidari, A. H., Zamiri, M. J., Nazem, M. N., Jafarzadeh Shirazi, M. R., Akhlaghi, A., & Ansari Pirsaraei, Z. (2021). Detrimental effects of long-term exposure to heavy metals on histology, size and trace elements of testes and sperm parameters in Kermani Sheep. Ecotoxicology and Environmental Safety, 207(October 2020), 111563. https://doi.org/10.1016/j.ecoenv.2020.111563
Kurniati, I. D., & Nugraheni, D. M. (2019). Efektivitas Pemberian Ekstrak Buah Kersen (Muntingia Calabura) terhadap Rasio Berat Testis pada Tikus yang Dipapar Asap Rokok. MEDICA ARTERIANA (Med-Art), 1(1), 15. https://doi.org/10.26714/medart.1.1.2019.15-21
Nsonwu-Anyanwu, A. C., Ekong, E. R., Offor, S. J., Awusha, O. F., Chukwuma, O. O., Umoh, E. I., Aleruchim, O. J., Rowland, E. F., & Opara, U. C. A. (2019). Heavy metals, biomarkers of oxidative stress and changes in sperm function: A case-control study. International Journal of Reproductive BioMedicine, 17(3), 155–166. https://doi.org/10.18502/2) 96-294-2
Rahmawati, F., Kurniaty, L., & Bintang, M. (2020). Antioxidant potential and identification of active compounds on Kabau seed (Archidendron bubalinum) flesh and husk extract. Jurnal Kimia Sains Dan Aplikasi, 23(3), 83–88. https://doi.org/10.14710/jksa.23.3.83-88
Riana, E. N., Aulia, S., Azizah, N., Khairani, I. A., Ariyanti, Y., Imaniar, L. H., & Setiawan, T. (2024). Phytochemical Screening and Antioxidant Activity of Kabau Seed Pod Extract from South Lampung. BIO Web of Conferences, 101.
https://doi.org/10.1051/bioconf/202410103003
Sri Gunawati, L., Ketut Berata, I., Luh Eka Setiasih, N., Pendidikan Sarjana Kedokteran Hewan, M., Patologi Veteriner, L., & Histologi Veteriner, L. (2019). Struktur Histopatologi Testis Tikus Wistar dengan Aktivitas Fisik Berlebih yang Diberikan Ekstrak Daun Kelor (Histopathological Structure of Wistar Rats Testicle with Excessive Physical Activities that Given Kelor Leaf Extract). Indonesia Medicus Veterinus, 8(5), 2477–6637. https://doi.org/10.19087/imv.2019.8.5.637
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